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公司: 沈陽萬類生物科技有限公司
貨號: WL02093 抗體名: SREBP-1抗體 抗體英文名: SREBP-1 antibody 濃度: >1mg/ml 應用范圍: WB,IHC 宿主: 兔 適應物種: H,M,R 標記物: 無 克隆性: 否 保存條件: -20℃ 形態: 液體 亞型: IgG 規格: 50μl(>50μg)
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產品貨號WL02093產品名稱SREBP-1 Antibody預測分子量mature SREBP-1 p68: 68kDaSREBP-1 p125 precursor : 125kDa別名ADD 1; bHLHd1; SREBF 1; SREBP1; Sterol regulatory element binding protein 1濃度>1 mg/ml免疫原合成SREBP-1多肽抗體來源兔特異性抗人、小鼠、大鼠克隆類型多克隆抗體產品應用WB;IHC成分親和純化抗體,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02%保存條件-20℃保存背景資料Sterol regulatory element–binding proteins (SREBPs) are basic helix-loop-helix–leucine zipper transcription factors, including SREBP-1 and SREBP-2. SREBP-1 is synthesized as a precursor that is attached to the nuclear envelope and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription.Among the isoforms of SREBPs, SREBP-1c activates all lipogenic genes in the liver. Phosphorylation of SREBP-1c at Ser372 by AMPK ihibits the proteolytic cleavage of SREBP-1c and therefore suppresses the expression of its target genes in the liver.
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