Anti-HFE2PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-HFE2 Polyclonal Antibody品牌：solarbio | 貨號：K003928P| 英文名稱 | Anti-HFE2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | HFE2A;HJV;JH;RGMC |
| 應用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應 | Human Rat |
| 蛋白分子量 | 45kDa |
| Gene ID | 148738 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human HFE2 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human HFE2 |
| Subcellular Locations | Cell membrane GPI-anchor Lipid-anchor |
| Swiss Prot | Q6ZVN8 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5′ UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. |
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