Anti-NPRL2PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-NPRL2 Polyclonal Antibody品牌：solarbio | 貨號：K007781P| 英文名稱 | Anti-NPRL2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | NPR2;NPR2L;TUSC4 |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:200-1000. IHC 1:50-200. |
| 交叉反應 | Human Mouse |
| 蛋白分子量 | 44kDa |
| Gene ID | 10641 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human NPRL2 |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human NPRL2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q8WTW4 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events. |
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