Anti-SPATA13PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-SPATA13 Polyclonal Antibody品牌：solarbio | 貨號：K006838P| 英文名稱 | Anti-SPATA13 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | ASEF2;ARHGEF29;RP11-307N16.3 |
| 應(yīng)用 | WB IHC |
| 稀釋比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反應(yīng) | Human Mouse |
| 蛋白分子量 | 75kDa |
| Gene ID | 221178 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human SPATA13 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human SPATA13 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q96N96 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity. |
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? 本文地址：http://www.gamefang.cn/thread-61383.htm
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