Anti-ATMPolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-ATM Polyclonal Antibody品牌：solarbio | 貨號(hào)：K004295P| 英文名稱(chēng) | Anti-ATM Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | AT1;ATA;ATC;ATD;ATDC;ATE;TEL1;TELO1 |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:500-1000. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 351kDa |
| Gene ID | 472 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲(chǔ)存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human ATM |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human ATM |
| Subcellular Locations | Cytoplasmic vesicle Nucleus |
| Swiss Prot | Q13315 |
| 克隆類(lèi)型 | Polyclonal Antibody |
| 背景資料 | The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. |
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