Anti-EID1PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-EID1 Polyclonal Antibody品牌：solarbio | 貨號：K007024P| 英文名稱 | Anti-EID1 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | CRI1;EID-1;RBP21;PTD014;C15orf3;PNAS-22;IRO45620 |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反應 | Human Mouse |
| 蛋白分子量 | 21kDa |
| Gene ID | 23741 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human EID1 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human EID1 |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | Q9Y6B2 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |
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