Anti-AXIN2PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-AXIN2 Polyclonal Antibody品牌：solarbio | 貨號：K006954P| 英文名稱 | Anti-AXIN2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | AXIL;ODCRCS |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:200-1000. IHC 1:25-100. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 94kDa |
| Gene ID | 8313 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human AXIN2 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human AXIN2 |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | Q9Y2T1 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
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