Anti-DFFAPolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-DFFA Polyclonal Antibody品牌：solarbio | 貨號：K006765P| 英文名稱 | Anti-DFFA Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | DFF1;ICAD;DFF-45 |
| 應用 | WB IHC |
| 稀釋比例 | WB 1:500-2000. IHC 1:30-150. |
| 交叉反應 | Human |
| 蛋白分子量 | 37kDa |
| Gene ID | 1676 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human DFFA |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human DFFA |
| Subcellular Locations | Nucleus Cytoplasm |
| Swiss Prot | O00273 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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