Anti-Phospho-NFκBp105-S927PolyclonalAntibody-一抗-抗體-蛋白與免疫
2023-10-29
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Anti-Phospho-NFκB p105-S927 Polyclonal Antibody| 英文名稱 | Rabbit Phospho-NFκB p105-S927 Polyclonal Antibody |
|---|---|
| 應用2 | WB |
| 克隆類型2 | Polyclonal Antibody |
| 別名 | CVID12;EBP-1;KBF1;NF-kB1;NF-kappa-B;NF-kappaB;NFKB-p105;NFKB-p50;NFkappaB;p105;p50 |
| 應用 | WB |
| 稀釋比例 | WB1:500-1:1000 |
| 交叉反應 | Human |
| 蛋白分子量 | 105kDa |
| Gene ID | 4790 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment. |
| 儲存液 | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A phospho specific peptide corresponding to residues surrounding S927 of human NFκB p105 |
| 性狀 | Lyophilized or Liquid |
| Swiss Prot | P19838 |
| 克隆類型 | Polyclonal Antibody |
| 來源 | Rabbit |
| 背景資料 | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. |
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