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RD TOCRIS一級(jí)代理，Z-Guggulsterone供應(yīng)CAS號(hào)39025-23-5

Catalog Number:3570

Chemical Name:(Z)-Pregna-4,17(20)-diene-3,16-dione

詳細(xì)產(chǎn)品信息：

Biological Activity

Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Kivalues are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki= 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activityin vivo. More active isomer ofguggulsterone(Cat. No. 2013).

Technical Data

M.Wt:

312.45

Formula:

C21H28O2

Solubility:

Soluble to 20 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming

Purity:

>98%

Storage:

Store at RT

CAS No:

39025-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.