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貨號: WL03667 保存條件: -20℃ 濃度: >1 mg/ml 應用范圍: WB 形態: 液體 亞型: IgG 適應物種: H,M,R 宿主: 兔 標記物: 無 抗體名: CDKN2A/p19ARF 抗體 抗體英文名: CDKN2A/p19ARF antibody 克隆性: 否 規格: 50μl(>50μg)
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產品貨號WL03667產品名稱CDKN2A/p19ARF Antibody預測分子量Predicted band size: 19 kDaObserved band size: 23 kDa別名ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P19; cyclin-dependent kinase inhibitor 2A; cyclin dependent kinase inhibitor 2A濃度>1 mg/ml免疫原合成CDKN2A/p19ARF多肽抗體來源兔特異性抗人、小鼠、大鼠克隆類型多克隆抗體產品應用WB成分親和純化抗體,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02%保存條件-20℃保存背景資料CDKN2A, also known as cyclin-dependent kinase Inhibitor 2A, is ubiquitously expressed in many tissues and cell types. p19ARF activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. p19ARF, which is unrelated to p16, arises from transcription of an alternative reading frame of the p16 gene. Like p16, p19ARF has been shown to induce cell cycle arrest. Mice lacking p19 ARF but expressing functional p16 have been shown to develop tumors early in life.
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